2024 Triphenylphosphonium cation

Triphenylphosphonium cation

Author: kwng

August undefined, 2024

WebThus, the triphenylphosphonium functional group should be considered for the development of photoantimicrobials for the selective killing of Gram-positive bacteria in the presence of … WebLipophilic phosphonium cations were first used to investigate mitochondrial biology by Vladimir Skulachev and colleagues in the late 1960s. Since then, these molecules have become important tools for exploring mitochondrial bioenergetics and free radical biology.

Targeting Antioxidants to Mitochondria by Conjugation to Lipophilic Cations

WebWe present an optimized procedure for synthesis of three [ 18 F]-labeled fluoroalkyl triphenylphosphoniumTriphenylphosphonium (TPP) salts ( [ 18 F]FATPs) via two-step … WebWe have previously reported that radiolabeled phosphonium cations accumulate in the mitochondria down a transmembrane potential gradient. We present an optimized … pheasant\u0027s-eyes yb

Lipophilic Triphenylphosphonium Cations Inhibit …

WebFeb 5, 2024 · As a lipophilic cation, triphenylphosphonium (TPP) has been commonly used in designing mitochondria‐targeted antioxidants. Conjugated with the TPP moiety, antioxidants can achieve more than 1000‐fold higher mitochondrial concentration depending on cell membrane potentials and mitochondrial membrane potentials. Herein we discuss … WebJul 1, 2008 · The use of the TPP cation to increase the antioxidant defences of mitochondria has been demonstrated to be a viable strategy in vitro. It has also been shown that … WebMay 1, 2008 · Abstract Mitochondria-targeted molecules comprising the lipophilic TPP (triphenylphosphonium) cation covalently linked to a hydrophobic bioactive moiety are used to modify and probe mitochondria in cells and in vivo. pheasant\u0027s-eyes yi

Efflux pump-mediated resistance to antifungal compounds can be …

Influence of Triphenylphosphonium (TPP) Cation …

WebHere, we describe protocols dealing with the preparation, mitochondria permeation assessment, electron paramagnetic resonance (EPR) spin trapping setting, and antiapoptotic properties evaluation of a series of new linear nitrones vectorized by a triphenylphosphonium cation and labeled with a diethoxyphosphoryl moiety as 31 P … WebFeb 23, 2007 · The cations lie in general positions except for A where the 1,2-bis (triphenylphosphonium)ethane cation lies at the centre of symmetry. It seems that for all the cations the description of the triphenylphosphonium moiety conformation (-PPh 3) the model reported by Dance & Scudder 14 could be useful. pheasant\u0027s-eyes ygWebFeb 19, 2015 · One of the most useful strategies in targeting molecules to mitochondria consist of the conjugation of drugs and bioactive molecules to lipophilic cations such as triphenylphosphonium (TPP), because they can rapidly cross phospholipid bilayers without requiring a transporter and can be easily taken up into mitochondria [9]. pheasant\u0027s-eyes yp

"WebMicelles Loaded With Puerarin And Modified With Triphenylphosphonium Cation Possess Mitochondrial Targeting And Demonstrate Enhanced Protective Effect Against Isoprenaline-Induced H9c2 Cells Apoptosis " - Triphenylphosphonium cation

Triphenylphosphonium cation

Mitochondria as a Novel Target for Cancer Chemoprevention

WebSep 1, 2024 · Triphenylphosphonium cation (TPP +), mitochondrial homing moiety with high lipophilicity, served as the frequently-used targeted moiety. For example, by attaching TPP+ as the mitochondrial homing moiety to α-tocopherol succinate, mito-vitamin E was shown to overcome drug resistance in lung carcinoma [17]. WebOct 21, 2007 · Mitoquinone is targeted to mitochondria by covalent attachment to a lipophilic triphenylphosphonium cation. Because of the large mitochondria membrane potential, the cations accumulate within cellular mitochondria up to 1,000 fold, compared to non-targeted antioxidants such as Coenzyme Q or its analogues, enabling the antioxidant …

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WebJun 2, 2011 · Triphenyl phosphonium cations (TPPs) are delocalized lipophilic cations that accumulate in the mitochondria of cells. We have explore the effect of increasing the … WebOct 21, 2024 · Methods: The mitochondriotropic polymer TPP-PEG-PE was synthesized for the preparation of PUE@TPP /PEG-PE micelles modified with triphenylphosphonium (TPP) cation. The physicochemical properties and anti-apoptosis effect of PUE@TPP /PEG-PE micelles were investigated. The coumarin 6 (C6)-labeled TPP/PEG-PE ( C6@TPP /PEG-PE) …

WebNov 30, 2024 · Triphenylphosphonium cation (TPP + ), a lipophilic cation, can easily pass through lipid bilayers due to its high lipophilicity and stable cationic charge, and the … WebOct 19, 2016 · The lipophilic triphenylphosphonium cation (TPP) has been the most widely used to direct a range of moieties to mitochondria in vivo, including redox probes, antioxidants and spin traps [ 2, 4, 5 ]. The TPP moiety is relatively easy to introduce into a compound by displacing a leaving group by reaction with triphenylphosphine [ 6 ].

WebAug 9, 2024 · Triphenylphosphonium-based modification of molecules facilitating mitochondria targeting is not a totally new concept as abundant literature already exists with regard to the potent biological effects exhibited by small molecules containing TPP +.28,32,33,40–44 Alkylated triphenylphosphonium cations initially were used as probes to … WebJan 5, 2024 · The triphenylphosphonium cation was used as an efficient means for selective delivery of known anticancer agents such as doxorubicin (Han et al. 2014) and …

WebTriphenylphosphonium Molecular Formula C H P Average mass 263.293 Da Monoisotopic mass 263.098419 Da ChemSpider ID 4410674 - Charge More details: Names Properties …

WebLipophilic cations such as phosphonium salts penetrate the hydrophobic barriers of the plasma and mitochondrial membranes and accumulate in mitochondria in response to … pheasant\u0027s-eyes yjWebA series of novel triphenylphosphonium (TPP) cations of the diterpenoid isosteviol (1, 16-oxo-ent-beyeran-19-oic acid) have been synthesized and evaluated in an in vivo … pheasant\u0027s-eyes yqWebOct 1, 2015 · Thus, 18F-labeled fluoroalkylphosphonium derivatives (18F-FATPs), including (5-18F-fluoropentyl)triphenylphosphonium cation (18F-FPTP), (6-18F-fluorohexyl)triphenylphosphonium cation (18F-FHTP), and (2-(2-18F-fluoroethoxy)ethyl)triphenylphosphonium cation (18F-FETP), were synthesized. The … pheasant\u0027s-eyes ykWebOct 1, 2024 · Triphenylphosphonium (TPP) cations have been used for the development of tumor or myocardial diagnostic radiopharmaceuticals. In this work, the development of … pheasant\u0027s-eyes yoWebApr 15, 2003 · Because alkyltriphenylphosphonium cations pass easily through lipid bilayers by non-carrier-mediated transport, they should be taken up by the mitochondria of all … pheasant\u0027s-eyes ylWebPhosphonium. 15 languages. Edit. Structure of PH+. 4, the parent phosphonium cation. In polyatomic cations with the chemical formula P R+. 4 (where R is a hydrogen or an alkyl, aryl, or halide group). These cations have tetrahedral structures. The salts are generally colorless or take the color of the anions. pheasant\u0027s-eyes ym pheasant\u0027s-eyes yh