WebBetween 1987 and 2009, approximately 115 cases of sucrose-containing IVIg induced kidney injury have been reported in the literature. Risk Factors Clinical trends showed that older age , diabetes , intravascular volume depletion especially in the setting of diuretic use and preexistent renal disease may predispose to the development of acute kidney injury in … Web8 Jun 2024 · The risk occurs more commonly with IVIG products that contain sucrose, which have largely been replaced by sucrose-free products. Despite the removal of sucrose from IVIG formulations, there are still potential risks associated with the use of these agents in patients with impaired kidney function.
Intravenous immunoglobulin SpringerLink
WebSucrose containing IVIg are the most widely used prepa-rations in USA. Disproportionate shares (88% of US reports) of IVIg induced Acute Kidney Injury (AKI) have been … Web18 Jul 2013 · Since the era of acute renal failure secondary to IVIG, sucrose (leading to 90% of cases of renal failure) has been removed from most IVIG products. Acute renal failure has become rare in the past years. Sucrose … most effective laxatives for gastroparesis
Renal Insufficiency and Failure Associated with Immune Globulin ...
WebSucrose is used as a transport and storage molecule in most plants due to its limited chemical reactivity. It can be used to prepare density gradients for the separation of cell/organelle. Sucrose can be used in the plant, insect, and bacterial culture media as a supplement. In addition, sucrose can also be used in several enzymatic assays. Web20 Jul 2024 · Renal dysfunction, acute renal failure, osmotic nephropathy, and death may occur with the administration of immune globulin intravenous (Human) (IGIV) products in predisposed patients. Renal dysfunction and acute renal failure occur more commonly in patients receiving IGIV products containing sucrose. Octagam® 10% does not contain … WebAll IVIG products have the potential to cause nephrotoxicity in patients that have underlying renal disease and/or take concurrent nephrotoxic drugs, although as stated in the Boxed Warning, the risk is signifcantly higher with products containing sucrose. As of 2024, there are currently no sucrose-containing IVIG products available in the US ... most effective learning