Web17 Oct 2024 · Fine-mapping aims to identify causal variants impacting complex traits. Several recent methods improve fine-mapping accuracy by prioritizing variants in … Web31 Jan 2024 · A substantial fraction of these identified loci are associated with multiple traits – a phenomena known as pleiotropy. Identification of pleiotropic associations can …
A Multiparent Advanced Generation Inter-Cross to Fine- Map
WebThe ultimate goal of GWAS is to identify a large portion of the common single-nucleotide genetic variation for association with a complex disease or variation in a quantitative trait. To develop new prevention and treatment strategies to who is at risk, it is important to understand the biological basis of genetic effects in developing new medical therapies. Web15 Jan 2024 · A more immediate fine-mapping approach is to directly measure the effect a variant can have on the strength of a regulatory … locally developed math
Fine mapping and accurate prediction of complex traits …
Web3 Aug 2024 · Multinomial fine-mapping (MFM) is an efficient approach for fine-mapping multiple diseases in datasets that share controls. This approach is able to efficiently … WebAdvancing from statistical associations of complex traits with genetic markers to understanding the functional genetic variants that influence traits is often a complex process. Fine-mapping can select and prioritize genetic variants for further study, yet the multitude of analytical strategies and study designs makes it challenging to choose an … Web6 May 2024 · However, mapping of the sensitive stage, especially at the reproductive phase of a complex trait, involves multiple genes, environment interactions, and difficulties in phenotypic screening. Despite these large numbers of QTLs for LTS, a few of them were studied for fine-mapping and cloning. locally developed test