2024 Robustness and lethality

Robustness and lethality

Author: fjqb

August undefined, 2024

To define a baseline for the robustness of the real biological molecular networks, we considered multiple versions of randomized models: (1) intra-layer randomized versions, where the randomization occurs within the gene regulatory, PPI, or metabolic layers; and (2) interlayer randomized versions, where … See more According to the central dogma of molecular biology, DNA is transcribed into RNA which is then translated into protein products. Moreover, many proteins can … See more To investigate how the couplings between the gene regulatory and PPI networks contribute to defining the system structure and function, we compared the effects … See more Gene perturbations can propagate to the metabolic network through the failure of enzymes. For example, consider the gene TCF7L2, one of the most replicated type … See more In a typical scenario, to quantify the multilayer network’s robustness, one needs to perform simulations on large-scale networks, which is time-consuming and … See more WebNov 27, 2024 · Robustness is a prominent feature of most biological systems. Most previous related studies have been focused on homogeneous molecular networks. Here we propose a comprehensive framework for understanding how the interactions between genes, proteins and metabolites contribute to the determinants of robustness in a …

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WebRobustness is a prominent feature of most biological systems, but most of the current efforts have been focused on studying homogeneous molecular networks. Here the authors propose a comprehensive framework for understanding how the interactions between genes, proteins, and metabolites contribute to the determinants of robustness. WebOct 28, 2024 · Abstract Robustness is a prominent feature of most biological systems. In … checkmate cd

Nat. Commun. 多层生物分子网络的鲁棒性研究 - 知乎

WebRobustness and lethality in multilayer biological molecular networks Downloadable! Robustness is a prominent feature of most biological systems. Most previous related studies have been focused on homogeneous molecular networks. WebDec 16, 2024 · challenging to identify new, robust synthetic lethal interactions in cancer due to a lack of understanding of what makes a gene pair likely to be synthetic lethal. As >60% of human genes have an identifiable paralog, and as paralog pairs are more likely to be synthetic lethal than random gene pairs, exploiting synthetic lethality among paralog WebRobustness is a prominent feature of most biological systems. Most previous related studies have been focused on homogeneous molecular networks. Here we propose a comprehensive framework for understanding how the interactions between genes, proteins and metabolites contribute to the determinants of robustness in a heterogeneous … checkmate cessna 172 checklist

Robustness and lethality

Centrality as a Predictor of Lethal Proteins: Performance and Robustness

WebSep 1, 2010 · Robustness affects evolvability in different ways. Biological organisms and computer programs are both encoded by a string of characters: DNA in organisms, binary code in programs. In biological systems, random mutations to DNA sequences are the fundamental source of long-term evolutionary adaptation. However, if one reduces a … Webmetabolites contribute to the determinants of robustness in a heterogeneous biological …

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WebNov 27, 2024 · We show that the proposed mechanism predicts a higher vulnerability of … WebOct 29, 2010 · Mild heat stress pretreatment provided a robustness advantage towards lethal heat stress treatment, and also conferred cross-protection towards lethal acid stress, whereas no increased resistance towards lethal oxidative stress was observed upon mild heat stress pretreatment ( Figure 2b ).

WebJan 1, 2024 · Synthetic lethality/sickness (SL) is a well-known type of genetic interaction, conceptualized as cell death or reduced cell viability that occurs under the combined inactivation of two genes but not under the inactivation of either gene alone. WebOct 28, 2024 · Abstract Abstract Robustness is a prominent feature of most biological systems. In a cell, the structure of the interactions between genes, proteins, and metabolites has a crucial role in maintaining the cell’s functionality and viability in presence of external perturbations and noise.

WebSep 15, 2024 · De Kegel et al. identified 22 features predictive of robust synthetic lethality between paralog pairs in cancer and used these features to develop a classifier that generates interpretable predictions of synthetic lethality for ∼36.6k human paralog pairs. WebRobustness is an inherent property of many biological systems and a fundamental feature of evolvability ( 1 , 2 ). Robust systems can maintain their functions or traits despite a dynamically changing environment, and thus possess enhanced fitness ( 3 ).

WebParenteral immunization of mice with the OPS-IpaB vaccine resulted in high levels of OPS- and IpaB-specific serum IgG and robust protection against lethal S. flexneri 2a or Shigella sonnei challenge. The OPS-IpaB vaccine is a promising new vaccine candidate with the capacity to confer broad protection against clinically relevant Shigella serotypes.

Web鲁棒性定义为系统在外界扰动或内在噪声存在的情况下仍保持自身功能的能力，这对大多数生物体的生存至关重要。以往的相关研究大多集中在孤立的分子网络上，如基因调控网络、蛋白质相互作用网络和代谢网络等。据生物体内的“中心法则”可知，不同生物分子之间联系紧密，共同决定着细胞的功能，如基因编码蛋白质，蛋白质调控基因的调控并参与代谢反应。 … flat branch rogers arWebHere, we discuss how to overcome these challenges and unveil the determinants of robustness and lethality of multilayer biological molecular networks, revealing the relationships between the critical structural features of a network and their functional importance in biology using a unified model. II. checkmate chapter 81WebJun 26, 2024 · First, by definition, these genetic interactions result in lethality, making mutant recovery and identification difficult. Second, many synthetic lethal interactions are condition-dependent... checkmate champions incWebApr 10, 2024 · The severe consequences of the Zika virus (ZIKV) infections resulting in congenital Zika syndrome in infants and the autoimmune Guillain–Barre syndrome in adults warrant the development of safe and efficacious vaccines and therapeutics. Currently, there are no approved treatment options for ZIKV infection. Herein, we describe the … checkmate caseWebNov 1, 2004 · Robustness is a ubiquitous feature of biological systems. It ensures that … checkmate chap 26WebNov 27, 2024 · For example, by applying percolation theory to the analysis of the … checkmate cessna 172s checklist pdfWeb1 day ago · In New Mexico, the rate of police using lethal force is even higher if a Black resident is involved. Black people total around 2.7% of the state's population, yet they are nearly four times more ... flat branch waynesville mo