WebThese efforts have revealed several acquired resistance mechanisms and candidates, including EGFR secondary mutations (T790M and other rare mutations), MET amplification, PTEN downregulation, CRKL amplification, high-level HGF expression, FAS-NFκB pathway activation, epithelial-mesenchymal transition, and conversion to … WebV-crk avian sarcoma virus CT10 oncogene homolog-like (CRKL) is a gene that encodes a SH2 and SH3 domain containing protein kinase. Missense, nonsense, and silent mutations are observed in cancers such as endometrial cancer, intestinal cancer, and stomach cancer. ... The most common alterations in CRKL are CRKL Amplification (0.51%), CRKL ...
Amplification of CRKL Induces Transformation and …
WebDec 1, 2009 · Our findings indicate that amplification and resultant overexpression of CRKL contribute to diverse oncogenic phenotypes in lung cancer, with implications for targeted therapy, and highlight a... Webhypothesized that CRKL was amplifying the HOX13–IGF cell-signalling axis to promote acral melanoma. To investigate this possibility, they turned to human melanoma cells grown in vitro. Using comprehensive protein analy-ses, the authors provide evidence that CRKL amplification in acral melanoma acts together ohio id back
CRKL - My Cancer Genome
WebThese results suggest that CRKL, but not MAPK1 is the target oncogene of the rare but recurrent amplification at 22q11.2 in laryngeal squamous cell carcinoma. differential … WebOct 20, 2015 · The focal amplicon contains five genes including CRKL, PI4KA, ZNF74, THAP7, and LZTR1. Out of 84 non-small cell lung cancer (NSCLC) cell lines, three cell lines with CRKL amplification confirmed by fluorescence in situ hybridization (FISH) were selected to study the functional significance. WebCrk Like Protein. The appearance of CRKL amplification in lung adenocarcinoma post-treatment with EGFR-inhibitors, suggests CRKL as an additional mediator of acquired resistance to epidermal growth factor receptor (EGFR)-inhibitors and credential it as a potential therapeutic target for a subset of NSCLC [52]. From: Cancer Treatment … my hero academia heroes rising fancaps